Spravato® (Esketamine) Treatment in Wichita

Innovative Care for Treatment-resistant Depression

If you’ve tried multiple treatments for depression without success, there may still be hope. As an FDA-approved nasal spray designed specifically for adults with treatment-resistant depression, Spravato® offers additional possibilities.

What is Spravato®?

Spravato® is a form of esketamine, derived from ketamine, which works differently from standard antidepressants. It is FDA-approved for adults with treatment-resistant depression – meaning symptoms have not improved with at least two other antidepressant medications. At KU Wichita Psychiatry & Behavioral Sciences clinics, we provide Spravato® nasal spray treatments in our clinic.

How Spravato® Works

Unlike traditional antidepressants, which can take weeks to work, Spravato® may provide noticeable relief within days to weeks.

Unique Mechanism

Unlike most antidepressants that target serotonin, Spravato® works on the brain’s glutamate system, helping to restore healthy brain connections.

Rapid Results

Some patients notice reduced depressive symptoms within hours to days of treatment.

Combination Approach

Spravato® is used alongside an oral antidepressant, creating a stronger treatment plan for long-lasting benefit.

What to Expect with Spravato® Treatment

Before Treatment

Your psychiatrist will review your medical history, depression treatment history and determine if Spravato® is right for you.

You’ll continue taking your prescribed oral antidepressant throughout treatment.

During Treatment

Spravato® is self-administered as a nasal spray under direct medical supervision.

After dosing, you’ll relax in a comfortable clinic setting for about two hours, where our staff will monitor you for safety and support.

After Treatment

You’ll need a responsible adult to drive you home. Patients cannot safely drive until the following day.

Temporary side effects may include dizziness, mild dissociation, or nausea, which usually resolve the same day.

Treatment Course

Initial Phase

Typically, Spravato® is administered twice per week for the first four weeks.

Maintenance Phase

Frequency decreases over time – usually once weekly, then every other week, depending on your progress.

Duration

Treatment is individualized. Some patients continue maintenance for several months or longer to sustain improvements.

Frequently Asked Questions

A referral from your psychiatrist or primary care provider can be helpful, but in many cases you may self-refer. Some insurance plans may require documentation of treatment history or a referral.
It varies. Many patients start with twice-weekly visits for one month, then taper them to less frequent sessions. Your provider will work with you to create a plan that fits your response and goals.

Yes. All visits and records are confidential and protected by HIPAA. Information is only shared with your consent or when legally required.
Yes. Spravato® is always prescribed in combination with an oral antidepressant. Many patients also continue psychotherapy for additional support.
Most insurance providers—including Medicare and some Medicaid plans—offer coverage for Spravato® when criteria for treatment-resistant depression are met. Our billing team will help verify benefits and minimize out-of-pocket costs.
No. You must arrange for a responsible adult to drive you home after every session. Driving is not allowed until the next day.

Ready to Take the Next Step?

Call 316-293-2647 to see if Spravato® is right for you or use the appointment request button to schedule. We look forward to partnering with you on your path to health and wellness.

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